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Acetylation

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Acetylation

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Mr.Luke Levin

Creative Proteomics

  • New York , United States

Business type:Manufacturer,Service

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Product Description

Acetylation is an important modification of proteins in cell biology. N-acetylation, or the transfer of an acetyl group to nitrogen, occurs in almost all eukaryotic proteins through both irreversible and reversible mechanisms. N-terminal acetylation requires the cleavage of the N-terminal methionine by methionine aminopeptidase (MAP) before replacing the amino acid with an acetyl group from acetyl-CoA by N-acetyltransferase (NAT) enzymes. It occurs as a co-translational and post-translational modification of proteins, for example, histones, STAT, and microtubules. Acetylation modification regulates protein conformation, and dysfunction of this modification has been implied in many diseases, including cancer. This type of acetylation is co-translational, in that N-terminus is acetylated on growing polypeptide chains that are still attached to the ribosome. While 80-90% of eukaryotic proteins are acetylated in this manner, the exact biological significance is still unclear.
Creative Proteomics is the proteomics division of Creative Dynamics Inc, an integrated CRO company that provides a full range of drug development services, including Molecular Biology, Biochemistry, Systems Biology, Organic Chemistry, Genomics, Bioinformatics, Structural Biology, Preclinical and Clinical studies. Creative Proteomics specializes in a full range of services to support various proteome-related researches from identification of single proteins to large-scale proteomic studies. We have one of the most advanced proteomics platforms in the world and our staff scientists are experienced proteomics professionals. Our proteome analysis platform provides protein separation, characterization, identification and quantification services, featured with high throughput and super-sensitivity. In addition, analyses of protein post-translational modifications such as phosphorylation and glycosylation are available.

Basic Information

  • Company Name:

    Creative Proteomics

  • Business Type:

    Manufacturer , Service

  • Product/Service:

    proteomics services , metabolomics services , bioinformatics services

  • No. of Total Employees:

    N/A

  • Product Range:

    Biological Products

  • Certificate:

    Manufacturer , Service

  • Company Address:

    45-16 Ramsey Road

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