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Acyl-CoAs are essential for many physiological processes, like lipid synthesis, fatty acid oxidation, ketone body generation, xenobiotic metabolism, and signaling transduction. Generally speaking, acyl-CoAs like free CoA, acetyl-CoA, and malonyl-CoA assist in regulation of metabolic flux. For example, glycolysis and fatty acid oxidation are regulated by the ratio of acetyl-CoA to free CoA. Another example is that the elevation of malonyl-CoA will lead to the synthesis of fatty acids and thereby inhibiting fatty acid oxidation by preventing acyl-CoA going into the mitochondrion. What`s more, the deacylation and acylation caused by various acyl-CoAs, like acetyl-CoA, palmitoyl-CoA and succinyl-CoA, plays an essential role in the function regulation of many proteins and genes. Acting as allosteric regulators of several enzymes and proteins, acyl-CoAs have a central role in many basic pathways.
Creative Proteomics is the proteomics division of Creative Dynamics Inc, an integrated CRO company that provides a full range of drug development services, including Molecular Biology, Biochemistry, Systems Biology, Organic Chemistry, Genomics, Bioinformatics, Structural Biology, Preclinical and Clinical studies.
Creative Proteomics specializes in a full range of services to support various proteome-related researches from identification of single proteins to large-scale proteomic studies. We have one of the most advanced proteomics platforms in the world and our staff scientists are experienced proteomics professionals. Our proteome analysis platform provides protein separation, characterization, identification and quantification services, featured with high throughput and super-sensitivity. In addition, analyses of protein post-translational modifications such as phosphorylation and glycosylation are available.