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Methionine Cycle Analysis Service
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Methionine (Met) is an essential amino acid. In the Methionine Cycle, methionine's methyl group becomes activated by ATP with the addition of adenosine to the sulfur of methionine, adjacent to the methyl group to form S−Adenosyl Methionine (SAMe). Removal of the methyl group from SAMe results in the formation of S−Adenosyl Homocysteine (SAH), which is immediately converted to the amino acid homocysteine by removal of the adenosine molecule. Homocysteine can then be modified in three different ways. In liver cells (and only in liver cells) homocysteine can irreversibly enter the transsulfuration pathway (catalyzed by Vitamin B6) to produce the amino acid cysteine. It has been estimated that 60% of homocysteine is metabolized by transsulfuration in the liver, with glucocorticoids increasing that percentage. Cysteine can be incorporated into proteins, can be used in the formation of the anti-oxidant molecule glutathione (GSH), or can be oxidized to form the amino acid taurine. If homocysteine does not enter the transsulfuration pathway, it can be converted back to methionine by the addition of a methyl group by one of two pathways. For one pathway of methyl group addition, methionine synthase enzyme catalyzes the transfer of a methyl group from methylated folic acid (MTHF) to homocysteine assisted by vitamin B12, which takes the methyl group from MTHF and adds it to the homocysteine. In another pathway (only in the liver), betaine (TMG) is the source of the methyl group transferred to homocysteine.
Creative Proteomics is the proteomics division of Creative Dynamics Inc, an integrated CRO company that provides a full range of drug development services, including Molecular Biology, Biochemistry, Systems Biology, Organic Chemistry, Genomics, Bioinformatics, Structural Biology, Preclinical and Clinical studies.
Creative Proteomics specializes in a full range of services to support various proteome-related researches from identification of single proteins to large-scale proteomic studies. We have one of the most advanced proteomics platforms in the world and our staff scientists are experienced proteomics professionals. Our proteome analysis platform provides protein separation, characterization, identification and quantification services, featured with high throughput and super-sensitivity. In addition, analyses of protein post-translational modifications such as phosphorylation and glycosylation are available.
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